This one may be best for my dad. He typically has several hundred emails in his inbox at any given time.
Grant Robinson has several ideas for keeping that e-mail inbox clear of messages to save you time thoughout the day.
I did a little house keeping myself and managed to get my inbox down to two messages that I've left in there simply as a reminder to respond to. I've set up other folders in Outlook along with rules to automatically sort my e-mail as it comes in.
I have one for Laurie, Family (immediate, extended and future), daily newsletters/emails and several others. It's kept my inbox clutter free all day. Now I don't sit sorting through as much e-mail. I only look at and respond to e-mails in particular categories, rather than sorting through a lot of other stuff that's not important.